Adenosine - Warnings and Precautions

Warnings Heart Block Adenosine Injection exerts its effect by decreasing conduction through the A-V node and may produce a short lasting first-, second- or third-degree heart block.

Appropriate therapy should be instituted as needed.

Patients who develop high-level block on one dose of adenosine injection should not be given additional doses.

Because of the very short half-life of adenosine, these effects are generally self-limiting.

Appropriate resuscitative measures should be available.

Transient or prolonged episodes of asystole have been reported with fatal outcomes in some cases.

Rarely, ventricular fibrillation has been reported following adenosine injection administration, including both resuscitated and fatal events.

In most instances, these cases were associated with the concomitant use of digoxin and, less frequently with digoxin and verapamil.

Although no causal relationship or drug-drug interaction has been established, adenosine injection should be used with caution in patients receiving digoxin or digoxin and verapamil in combination.

Arrhythmias at Time of Conversion At the time of conversion to normal sinus rhythm, a variety of new rhythms may appear on the electrocardiogram.

They generally last only a few seconds without intervention, and may take the form of premature ventricular contractions, atrial premature contractions, atrial fibrillation, sinus bradycardia, sinus tachycardia, skipped beats, and varying degrees of A-V nodal block.

Such findings were seen in 55% of patients.

Bronchoconstriction Adenosine Injection is a respiratory stimulant (probably through activation of carotid body chemoreceptors) and intravenous administration in man has been shown to increase minute ventilation (Ve) and reduce arterial PCO 2 causing respiratory alkalosis.

Adenosine administered by inhalation has been reported to cause bronchoconstriction in asthmatic patients, presumably due to mast cell degranulation and histamine release.

These effects have not been observed in normal subjects.

Adenosine Injection has been administered to a limited number of patients with asthma and mild to moderate exacerbation of their symptoms has been reported.

Respiratory compromise has occurred during adenosine infusion in patients with obstructive pulmonary disease.

Adenosine Injection should be used with caution in patients with obstructive lung disease not associated with bronchoconstriction (e.g., emphysema, bronchitis, etc.) and should be avoided in patients with bronchoconstriction or bronchospasm (e.g., asthma).

Adenosine Injection should be discontinued in any patient who develops severe respiratory difficulties.