Bupropion Overdose

10 OVERDOSAGE 10.1 Human Overdose Experience Overdoses of up to 30 grams or more of bupropion have been reported.

Seizure was reported in approximately one third of all cases.

Other serious reactions reported with overdoses of bupropion alone included hallucinations, loss of consciousness, sinus tachycardia, ECG changes such as conduction disturbances or arrhythmias, mental status changes,clonus, myoclonus, and hyperreflexia.

Fever, muscle rigidity, rhabdomyolysis, hypotension, stupor, coma, and respiratory failure have been reported mainly when bupropion was part of multiple drug overdoses.

Although most patients recovered without sequelae, deaths associated with overdoses of bupropion alone have been reported in patients ingesting large doses of the drug.

Multiple uncontrolled seizures, bradycardia, cardiac failure, and cardiac arrest prior to death were reported in these patients.

10.2 Overdosage Management Consult a Certified Poison Control Center for up-to-date guidance and advice.

Call 1-800-222-1222 or refer to www.poison.org.

There are no known antidotes for bupropion.

In case of an overdose, provide supportive care, including close medical supervision and monitoring.

Consider the possibility of multiple drug overdose.