FDA Section 4 \u2022 who must NOT take this
Spironolactone - Contraindications
These conditions, allergies, and situations mean Spironolactone should NOT be used. From the US FDA-approved drug label Section 4.
CONTRAINDICATIONS Spironolactone and hydrochlorothiazide tablets are contraindicated in patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, hypercalcemia, hyperkalemia, Addison’s disease, and in patients who are allergic to thiazide diuretics or to other sulfonamide-derived drugs.
Spironolactone and hydrochlorothiazide may also be contraindicated in acute or severe hepatic failure.