Simvastatin - Contraindications
These conditions, allergies, and situations mean Simvastatin should NOT be used. From the US FDA-approved drug label Section 4.
4 CONTRAINDICATIONS Ezetimibe and simvastatin tablets are contraindicated in the following conditions: • Concomitant use of strong CYP3A4 inhibitors (select azole anti-fungals, macrolide antibiotics, anti-viral medications, and nefazodone) [see Drug Interactions ] . • Concomitant use of cyclosporine, danazol, or danazol [see Drug Interactions ] . • Acute liver failure or decompensated cirrhosis [see Warnings and Precautions ] . • Hypersensitivity to simvastatin, ezetimibe, or any excipients in ezetimibe and simvastatin tablets.
Hypersensitivity reactions, including anaphylaxis, angioedema, and Stevens-Johnson syndrome, have been reported [see Adverse Reactions ] . • Concomitant use of strong CYP3A4 inhibitors (select azole anti-fungals, macrolide antibiotics, anti-viral medications and nefazodone). • Concomitant use of cyclosporine, danazol or gemfibrozil. • Acute liver failure or decompensated cirrhosis. • Hypersensitivity to simvastatin, ezetimibe or any excipient of ezetimibe and simvastatin tablets.