Silodosin - Contraindications
These conditions, allergies, and situations mean Silodosin should NOT be used. From the US FDA-approved drug label Section 4.
4 CONTRAINDICATIONS Severe renal impairment (CCr <30 mL/min) Severe hepatic impairment (Child-Pugh score ≥10) Concomitant administration with strong Cytochrome P450 3A4 (CYP3A4) inhibitors (e.g., ketoconazole, clarithromycin, itraconazole, ritonavir) [ see Drug Interactions ] Patients with a history of hypersensitivity to silodosin or any of the ingredients of silodosin capsules [ see Adverse Reactions and Description ] Patients with severe renal impairment [Creatinine Clearance (CCr <30 mL/min)].
Patients with severe hepatic impairment (Child-Pugh score ≥ 10).
Concomitant administration with strong Cytochrome P450 3A4 (CYP3A4) inhibitors (e.g., ketoconazole, clarithromycin, itraconazole, ritonavir).
Patients with a history of hypersensitivity to silodosin or any of the ingredients of silodosin capsules.