FDA Section 4 \u2022 who must NOT take this
Isosorbide dinitrate - Contraindications
These conditions, allergies, and situations mean Isosorbide dinitrate should NOT be used. From the US FDA-approved drug label Section 4.
CONTRAINDICATIONS Isosorbide dinitrate is contraindicated in patients who are allergic to isosorbide dinitrate or any of its other ingredients.
Do not use isosorbide dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil.
Concomitant use can cause severe hypotension, syncope, or myocardial ischemia.
Do not use isosorbide dinitrate in patients who are taking the soluble guanylate cyclase stimulator riociguat.
Concomitant use can cause hypotension.