FDA Section 12 \u2022 mechanism \u2022 pharmacokinetics
Imipramine - How It Works
Clinical pharmacology details from the US FDA-approved label: how Imipramine works in your body, how it's absorbed, how long it stays active, and how it's eliminated.
CLINICAL PHARMACOLOGY The mechanism of action of imipramine hydrochloride is not definitely known.
However, it does not act primarily by stimulation of the central nervous system.
The clinical effect is hypothesized as being due to potentiation of adrenergic synapses by blocking uptake of norepinephrine at nerve endings.
The mode of action of the drug in controlling childhood enuresis is thought to be apart from its antidepressant effect.